GARLIC
- Source:
- Garlic is a member of the lily family and belongs to the genus Allium, which also includes onions. Garlic is currently no longer found in the wild and has evolved to its present form after thousands of years of cultivation. Garlic bulbs are harvested in early summer with the largest production in central California, followed by China.
- Effects:
- The primary indications for the use of garlic include hyperlipidemia, mild hypertension, early stages of intermittent claudication, cardiovascular disease in general, and when an overall antiviral, antifungal and/or antibiotic agent is necessary. Garlic has also been used throughout the centuries for intestinal problems, infections, weight loss, low-energy, respiratory problems, as well as others.
- Dosage:
- The recommended dose for garlic is to chew one fresh clove of garlic per day. It can also be taken in odor controlled enteric-coated garlic powder capsules. The supplement should provide at least 5000mcg of allicin per day with the treatment period being for 3 to 6 months.
- Side Effects:
- Consumption at these doses has minimal to no side effects or contraindications, although heartburn and flatulence may occur. Garlic odor may be experienced with perspiration, which can be avoided by taking, the supplements in two or three smaller divided dosages. There are allergic reactions to garlic but they are extremely rare. Contraindications would include using anti coagulant drugs with garlic. There are no known contraindications for use during pregnancy or lactation.
Garlic cloves before they are crushed or chewed are high in the sulfur containing compound known as Alliin. With crushing or chewing, alliin is altered due to contact with the enzyme allinase. Allinase transforms Alliin into Allicin, which is the source of the typical garlic odor. The Allicin however is very unstable and depending upon environmental conditions it commonly breaks down into a number of other sulfur compounds. Research has demonstrated that garlic supplements work best when they approximate eating raw garlic. However carefully prepared garlic powder supplements can yield only 4% less Allicin than raw garlic.
Garlic has been shown to effectively lower serum cholesterol and triglycerides, inhibit platelet aggregation, increase fibrinolysis and possess mild anti-hypertensive effects. Garlic interferes with the hepatic metabolism of cholesterol resulting in less release into the serum, mildly elevates HDL cholesterol and prevents oxidation of LDL cholesterol. There have been over 32 human studies since 1975 demonstrating lipid lowering effects of garlic. The majority of studies were completed with garlic powder tablets that are standardized to 1.3% alliin. The daily dosage of these studies ranged between 600mg to 900mg. This provided approximately 5000mcg of allicin potential at the higher dose. The studies ranged from 4 weeks to 16 weeks. In meta-analysis studies since 1975 the average reduction in total serum cholesterol of garlic treatment was found to be 9% to 12% and reduction of serum triglycerides from 8% to 27%. Garlic however is not as aggressive as cholesterol lowering drugs, but does appear to be safe for long term use. Once aggressive drug therapy has been completed, garlic can be used as a preventative measure.
Garlic’s ability to inhibit platelet aggregation and increase fibrinolysis has been demonstrated in multiple studies. Therefore, consuming a diet high in garlic may decrease the incidence of cardiovascular disease and prevent or treat early stages of peripheral vascular conditions such as intermittent claudication.
Garlic also has been shown to have anti-viral, anti-fungal and anti-bacterial activity. It was first shown to be anti-bacterial by Dr. Pasterur in 1858, although it is weak and only contains 1% of the anti bacterial potential of penicillin. Therefore it is not useful to fight infection but rather used as an adjunctive therapy for persons who have recurrent infections. Garlic has also been found to inhibit the virus herpes simplex, cytomegalovirus and also the human immuno deficiency virus. The anti HIV activity has been associated with a different active component other than the allicin. Garlic has also been shown to inhibit candida albicans, which is a fungal type of infection.
Epidemiological studies have also demonstrated that regular garlic intake has been shown to reduce esophageal, stomach and colon cancers. Garlic may be able to reduce the formation of N-nitroso compounds such as nitrosamine. Animal studies both in-vitro and in-vivo have shown garlic and its sulfur compounds to inhibit the growth of different cancer cells, particularly breast and skin tumors.